反应详情

2-(Trifluoroacetyl)-1H-pyrrole (0.97 g) was added to DMF solution (10 ml) of 60% sodium hydride (0.16 g) and the mixture was stirred at room temperature for 30 minutes. 3-Methyl-4-nitrobenzyl chloride (1.0 g) was added thereto and the mixture was stirred at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitrobenzyl)-2-(trifluoroacetyl)-1H-pyrrole (1.53 g).

1. stirringthe mixture was stirred at room temperature for 2 hours
2. washwashed with water and saturated aqueous solution of sodium chloride
3. dry with materialAfter drying the organic layer with magnesium sulfate
4. distillationthe solvent was distilled off under the reduced pressure
5. customthe obtained residue was purified by silica gel column chromatography