Triethylamine → HCID 86076326, compound

HRID 2243282Notes

Reaction equation

HRID 2243282 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[NH:7][N:6]=[C:5]([SH:8])[N:4]=1.[F:11][C:12]([F:21])([F:20])[C:13]([F:19])([F:18])[C:14]([F:17])([F:16])I.C(N(CC)CC)C>CN(C=O)C.C(OCC)(=O)C>[F:18][C:13]([F:19])([C:12]([F:21])([F:20])[F:11])[C:14]([S:8][C:5]1[N:4]=[C:3]([C:2]([F:10])([F:9])[F:1])[NH:7][N:6]=1)([F:17])[F:16]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 33977Perfluoropropyl iodideHCID 178506278HCID 178506278, compound

Product 1

HCID 86076326HCID 86076326, compoundYield 17.6%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

5-Trifluoromethyl-1H-(1,2,4)-triazole-3-thiol (11.0 g), heptafluoro-1-iodopropane (3.5 g) and triethylamine (0.90 g) were stirred in DMF (10 ml) at 90° C. for 24 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 3-heptafluoropropylsulfanyl-5-trifluoromethyl-1H-(1,2,4)-triazole (0.70 g).

Workup

  1. washwashed with water and saturated aqueous solution of sodium chloride
  2. dry with materialAfter drying the organic layer with magnesium sulfate
  3. distillationthe solvent was distilled off under the reduced pressure

Sources & evidence

ORD record
ord-d978de2a7d2b49fdaef6fcbf3c5c3439
Source dataset
uspto-grants-2010_03
Patent number
US07674807B2

Reaction notes

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