Lithium Hydroxide → HCID 11718381, compound

HRID 2243498Notes

Reaction equation

HRID 2243498 reaction equation
C[O:2][C:3]([C:5]1[S:23][C:8]2[C:9]3[CH:10]=[CH:11][C:12]([NH:16][CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)=[CH:13][C:14]=3[S:15][C:7]=2[C:6]=1[O:24][CH2:25][C:26]([O:28]CC)=[O:27])=[O:4].[Li+].[OH-]>C1COCC1>[C:26]([CH2:25][O:24][C:6]1[C:7]2[S:15][C:14]3[CH:13]=[C:12]([NH:16][CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[CH:11]=[CH:10][C:9]=3[C:8]=2[S:23][C:5]=1[C:3]([OH:4])=[O:2])([OH:28])=[O:27]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 68543727HCID 68543727, compound

Product 1

HCID 11718381HCID 11718381, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6-cyclohexylamino-1-ethoxycarbonylmethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester (23 mg, 0.05 mmol) in THF/H20 was added 2.OM aq. LiOH solution (0.125 mL, 0.25 mmol) at room temperature. After stirring at this tempterature overnight, the reaction mixture was concentrated, and acidified with 10% HCl. The product was collected by filtration and washed with water as a white solid (13.2 mg, 63%).

Workup

  1. concentrationthe reaction mixture was concentrated
  2. filtrationThe product was collected by filtration
  3. washwashed with water as a white solid (13.2 mg, 63%)

Sources & evidence

ORD record
ord-eb7a948db3a2483ba99c848bbc72b13b
Source dataset
uspto-grants-2010_03
Patent number
US07674822B2

Reaction notes

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