HCID 58608093, compound → HCID 58608127, compound

HRID 2243590Notes

Reaction equation

HRID 2243590 reaction equation
C([N:8]1[CH:13]=[CH:12][C:11](=[O:14])[C:10]2[C:15]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[C:16]([Si:18]([CH2:23][CH3:24])([CH2:21][CH3:22])[CH2:19][CH3:20])[O:17][C:9]1=2)C1C=CC=CC=1>C(OCC)(=O)C.CO.[OH-].[OH-].[Pd+2]>[C:25]1([C:15]2[C:10]3[C:11](=[O:14])[CH:12]=[CH:13][NH:8][C:9]=3[O:17][C:16]=2[Si:18]([CH2:21][CH3:22])([CH2:23][CH3:24])[CH2:19][CH3:20])[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 1

HCID 58608093HCID 58608093, compound

Product 1

HCID 58608127HCID 58608127, compound

Reagents, catalysts & solvents 3

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 7-benzyl-3-phenyl-2-(triethylsilanyl)-7H-furo[2,3-b]pyridin-4-one (1) and Pd(OH)2 (0.11 g 20% on C, 0.11 mmol) in ethyl acetate (10 mL) and methanol (10 mL) was degassed and stirred under hydrogen at room temperature for 2.5 hr. The catalyst was filtered off and the solvent was removed to give the title compound. MS (m/z), M+H+ 326.0.

Workup

  1. customwas degassed
  2. filtrationThe catalyst was filtered off
  3. customthe solvent was removed

Sources & evidence

ORD record
ord-2302e03a22d6489ba53ed699d12f6149
Source dataset
uspto-grants-2010_03
Patent number
US07674907B2

Reaction notes

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