反应详情

A mixture of 13.8 parts of 1H-1,2,4-triazole, 18.7 parts of 1-bromo-4-methoxybenzene, 5 parts of potassium carbonate, 0.5 parts of copper (I)chloride and 90 parts of N,N-dimethylformamide is stirred and refluxed for 2 days. The reaction mixture is cooled and poured onto water. The product is extracted twice with benzene. The combined extracts are washed with water, dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using trichloromethane as eluent. The pure fractions are collected and the eluent is evaporated. The residue is triturated in 2,2'-oxybispropane. The product is filtered off and dried, yielding 7.8 parts (44.5%) of 1-(4-methoxyphenyl)-1H-1,2,4-triazole; mp. 99.4° C.

1. temperaturerefluxed for 2 days
2. temperatureThe reaction mixture is cooled
3. additionpoured onto water
4. extractionThe product is extracted twice with benzene
5. washThe combined extracts are washed with water
6. customdried
7. filtrationfiltered
8. customevaporated
9. customThe residue is purified by column-chromatography over silica gel
10. customThe pure fractions are collected
11. customthe eluent is evaporated
12. customThe residue is triturated in 2,2'-oxybispropane
13. filtrationThe product is filtered off
14. customdried