1,2-Dichloroethane → HCID 11577035, compound

HRID 2244991Notes

Reaction equation

HRID 2244991 reaction equation
CN1CCN=C1[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:34])[CH:15]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[CH3:33])[NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[O:18])=[CH:9][CH:8]=1.[CH3:35][N:36]1[CH2:42][CH2:41][CH2:40][N:39](C2C=CC(N)=CC=2)[CH2:38][CH2:37]1.C(Cl)CCl>CN(C=O)C.O>[CH3:35][N:36]1[CH2:42][CH2:41][CH2:40][N:39]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:34])[CH:15]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[CH3:33])[NH:16][C:17]([NH:19][C:20]3[CH:21]=[CH:22][C:23]([Cl:26])=[CH:24][CH:25]=3)=[O:18])=[CH:11][CH:12]=2)[CH2:38][CH2:37]1

Participants

6

Reactant 3

HCID 111,2-DichloroethaneHCID 130079514-(4-Methyl-1,4-diazepan-1-yl)anilineHCID 58674790HCID 58674790, compound

Product 1

HCID 11577035HCID 11577035, compoundYield 38%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetic acid (from EXAMPLE 84, 40 mg, 0.13 mmol) and 4-(4-methyl-homopiperazinyl)phenylamine (61 mg, 0.25 mmol) in DMF (3 mL) and H2O (1 mL), EDC (96 mg, 0.50 mmol) was added. After being stirred at room temperature for 2 h, the mixture was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (25 mg). MS 506.2 and 508.2 (M+H, Cl pattern).

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was purified by HPLC

Sources & evidence

ORD record
ord-08800b987de34e939d775d8e9dcf48fd
Source dataset
uspto-grants-2010_03
Patent number
US07678913B2

Reaction notes

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