Hydrochloric Acid → HCID 68549802, compound

HRID 2245281Notes

Reaction equation

HRID 2245281 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:4].O[Li].O.COC(C)(C)C.[ClH:25]>CO.C1COCC1.O>[ClH:25].[F:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[N:6][C:5]([C:3]([OH:4])=[O:2])=[CH:14]2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 15413tert-Butyl methyl etherHCID 168937Lithium hydroxide, monohydrateHCID 57947434Methyl 6-fluoroisoquinoline-3-carboxylate

Product 1

HCID 68549802HCID 68549802, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

1 g of the resulting crude 6-fluoro-isoquinoline-3-carboxylic acid methyl ester is dissolved in 20 ml of MeOH/THF (1:1) and slowly mixed at 5° with a solution of 510 mg of LiOH hydrate in 10 ml of water. The resulting solution is stirred at room temperature overnight and poured into a solution consisting of 50 ml of MeOtBu, 10 ml of water and 7 ml of 2N aqu. HCl. The precipitate is filtered off and washed with MeOtBu.

Workup

  1. additionpoured into a solution
  2. filtrationThe precipitate is filtered off
  3. washwashed with MeOtBu

Sources & evidence

ORD record
ord-1b988d3aa9264f63bcab1ae672f80981
Source dataset
uspto-grants-2010_03
Patent number
US07683075B2

Reaction notes

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