Iodoethane → HCID 59216851, compound

HRID 2245635Notes

Reaction equation

HRID 2245635 reaction equation
O[C:2]1[C:10]([O:11][C:12]([F:15])([F:14])[F:13])=[CH:9][CH:8]=[CH:7][C:3]=1C(O)=O.I[CH2:17][CH3:18].C(=O)([O-])[O-:20].[Cs+].[Cs+].[C:25]([O:28][CH2:29]C)(=[O:27])C>CN(C)C=O>[CH3:29][O:28][C:25](=[O:27])[C:7]1[CH:8]=[CH:9][C:10]([O:11][C:12]([F:13])([F:14])[F:15])=[CH:2][C:3]=1[O:20][CH2:17][CH3:18]

Participants

6

Reactant 4

HCID 6340IodoethaneHCID 8857Ethyl AcetateHCID 10796Cesium carbonateHCID 121796552-Hydroxy-3-(trifluoromethoxy)benzoic acid

Product 1

HCID 59216851HCID 59216851, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.0 g 2-hydroxy-(trifluoromethoxy)benzoic acid were dissolved in 30 ml dimethylformamide. 640 mg iodoethane and 4.70 g cesium carbonate were added and the reaction mixture was stirred at room temperature for three hours. The reaction mixture was diluted by addition of 100 ml ethyl acetate, washed with 30 ml water and brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 590 mg 2-ethoxy-4-trifluoromethoxy-benzoic acid methyl ester.

Workup

  1. washwashed with 30 ml water and brine
  2. dry with materialdried over MgSO4
  3. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-090aee51c18147b2b398639f9518ae34
Source dataset
uspto-grants-2010_03
Patent number
US07683181B2

Reaction notes

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