反应详情

The amide (III) (1.3 g, 4 mmole) was suspended in 5 ml THF and 10 ml DMF. To this mixture was added cyanuric chloride (0.370 g, 2 mmole) and after stirring at room temperature for 0.5 hour, the reaction mixture was partitioned between ethylacetate and brine; the organic layer was washed with 5% sodium bicarbonate, followed by brine and then dried over sodium sulfate. Purification by flash chromatograpy on silica gel column using 75% ethylacetate in hexane as eluent afforded 1.2 g (98% yield) of nitrile (IV).

1. customthe reaction mixture was partitioned between ethylacetate and brine
2. washthe organic layer was washed with 5% sodium bicarbonate
3. dry with materialdried over sodium sulfate
4. customPurification by flash chromatograpy on silica gel column