Triphenylphosphine → HCID 10207804, compound

HRID 2246062Notes

Reaction equation

HRID 2246062 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[N:10]2[CH2:13][CH:12](O)[CH2:11]2)=[CH:5][CH:4]=1.[N:22]1[C:31]2[C:26](=[CH:27][C:28]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:29][CH:30]=2)[CH:25]=[CH:24][CH:23]=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[N:10]2[CH2:13][CH:12]([N:32]([C:28]3[CH:27]=[C:26]4[C:31](=[CH:30][CH:29]=3)[N:22]=[CH:23][CH:24]=[CH:25]4)[S:33]([CH3:36])(=[O:34])=[O:35])[CH2:11]2)=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 53715168HCID 53715168, compoundHCID 67159504HCID 67159504, compound

Product 1

HCID 10207804HCID 10207804, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

reaction of 1-[bis(4-chlorophenyl)methyl]azetidin-3-ol hydrobromide with N-quinolin-6-ylmethanesulfonamide in the presence of DIAD and triphenylphosphine in toluene, to form N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-yl-methylsulfonamide (the reaction is preferably performed at a temperature of between 40 and 60° C.), and then

Sources & evidence

ORD record
ord-9622cd16fef84ac38b55ca7256e51d5c
Source dataset
uspto-grants-2010_03
Patent number
US07687493B2

Reaction notes

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