2-Methoxypyridine → HCID 25260922, compound

HRID 2246538Notes

Reaction equation

HRID 2246538 reaction equation
I[CH2:2][CH2:3][CH2:4][Si:5]([CH3:35])([CH3:34])[CH2:6][CH2:7][C:8]1[C:20]2[CH2:19][N:18]3[C:13](=[CH:14][C:15]4[C@:25]([CH2:27][CH3:28])([OH:26])[C:24](=[O:29])[O:23][CH2:22][C:16]=4[C:17]3=[O:21])[C:12]=2[N:11]=[C:10]2[CH:30]=[CH:31][CH:32]=[CH:33][C:9]=12.C[O:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=1>CN(C)C=O>[CH3:34][Si:5]([CH3:35])([CH2:4][CH2:3][CH2:2][N:39]1[CH:40]=[CH:41][CH:42]=[CH:43][C:38]1=[O:37])[CH2:6][CH2:7][C:8]1[C:20]2[CH2:19][N:18]3[C:13](=[CH:14][C:15]4[C@:25]([CH2:27][CH3:28])([OH:26])[C:24](=[O:29])[O:23][CH2:22][C:16]=4[C:17]3=[O:21])[C:12]=2[N:11]=[C:10]2[CH:30]=[CH:31][CH:32]=[CH:33][C:9]=12

Participants

4

Reactant 2

HCID 742012-MethoxypyridineHCID 25260767HCID 25260767, compound

Product 1

HCID 25260922HCID 25260922, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of Compound 12 (60 mg) and 2-methoxypyridine (0.1 mL) in N,N-dimethylformamide (1 mL) was heated at 70° C. for 16 hours. The reaction mixture was concentrated under vacuum and the residue was directly eluted on a silica gel column using 4% ethanol in dichloromethane to obtain the required product in 60% yield (34 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. washthe residue was directly eluted on a silica gel column

Sources & evidence

ORD record
ord-82c0a5bf5f8b49ceb27f0ee0055202fb
Source dataset
uspto-grants-2010_03
Patent number
US07687496B2

Reaction notes

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