Ammonia → HCID 178516128, compound

HRID 2246824Notes

Reaction equation

HRID 2246824 reaction equation
[F:1][C:2]([C:5]([CH2:13][CH2:14]C)=[C:6](OCC)OCC)([F:4])[F:3].[N:16]#N.N.C1[CH2:23][O:22]CC1>[B]>[OH:22][C:23]1[CH:6]=[C:5]([C:2]([F:1])([F:3])[F:4])[CH:13]=[CH:14][N:16]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 947NitrogenHCID 8028TetrahydrofuranHCID 131728020HCID 131728020, compound

Product 1

HCID 178516128HCID 178516128, compound

Reagents, catalysts & solvents 1

HCID 5462311BoronCatalyst

Procedure

5 g (0.036 mol) trifluoromethyldiethoxypentene acid ethyl ester (mixture of isomers) were dissolved in 40 g THF. The solution was metered during 150 minutes into a 250° C. hot tube reactor, which was filled with a boron doped zeolite catalyst. As carrier gas a mixture of 100 l N2/h and as reactant 50 l NH3/h were pumped through the reactor. The outcoming gas was cooled and quenched into THF yielding to a mixture auf 90% of the desired product as well as 5% 2-ethoxy-4-(trifluoromethyl)pyridine.

Workup

  1. temperatureThe outcoming gas was cooled
  2. customquenched into THF yielding to a mixture auf 90% of the desired product as well as 5% 2-ethoxy-4-(trifluoromethyl)pyridine

Sources & evidence

ORD record
ord-8c09ed90bfcd4dc18b8f8a64ef2fce2f
Source dataset
uspto-grants-2010_03
Patent number
US07687632B2

Reaction notes

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