HCID 85861649, compound → HCID 85861650, compound

HRID 2247366Notes

Reaction equation

HRID 2247366 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[S:8][C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)=[C:10]([CH3:12])[N:11]=1)=[O:5])[CH3:2]>C1COCC1.CCOC(C)=O.[Pd]>[NH2:19][C:15]1[CH:14]=[C:13]([C:9]2[S:8][C:7]([NH:6][C:4]([NH:3][CH2:1][CH3:2])=[O:5])=[N:11][C:10]=2[CH3:12])[CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 1

HCID 85861649HCID 85861649, compound

Product 1

HCID 85861650HCID 85861650, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

A stirred solution of 1-Ethyl-3-[4-methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-urea (98c) (0.55 g, 1.8 mmol) in THF (25 ml) and EtOAc (50 ml) under Argon is treated with 10% palladium on carbon (1.0 g). The reaction mixture was placed under an atmosphere of hydrogen for 2 hours. The mixture was then filtered through Celite™ filter material and the solvent removed in vacuo to yield the titled compound.

Workup

  1. filtrationThe mixture was then filtered through Celite™
  2. filtrationfilter material
  3. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-ac2fcc4ef289490c8223dcd6774fd475
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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