反应详情

205 mg of Methyl (3′-hydroxy-4′-methoxybiphenyl-3-yl)acetate was dissolved in 3 ml of N,N-dimethylformamide, then 205 mg of glycidyl nocylate, 35 mg of cesium fluoride and 130 mg of potassium carbonate were added thereto, and the mixture was stirred at room temperature for 3 days. The reaction mixture was diluted with ethyl acetate and washed with 1N hydrochloric acid. The organic layer was dried over anhydrous magnesium sulfate and then filtered, and the filtrate was concentrated. The residue was purified by silica gel column chromatography, to give 79 mg of the title compound in the 4:1 hexane-ethyl acetate fraction.

1. washwashed with 1N hydrochloric acid
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. filtrationfiltered
4. concentrationthe filtrate was concentrated
5. customThe residue was purified by silica gel column chromatography