Hydrochloric Acid → 2-Methyl-3-(2-morpholinoethylcarbamoyl)-6-(3-nitrophenyl)-4-phenylpyridine dihydrochloride

HRID 2247867노트

반응식

HRID 2247867 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=O)[CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[O:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][NH:28][C:29](=[O:34])[CH2:30][C:31]([CH3:33])=O)[CH2:22][CH2:21]1.C([O-])(=O)C.[NH4+:39].[ClH:40]>CO>[ClH:40].[ClH:40].[CH3:33][C:31]1[C:30]([C:29](=[O:34])[NH:28][CH2:27][CH2:26][N:23]2[CH2:24][CH2:25][O:20][CH2:21][CH2:22]2)=[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[C:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[N:39]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3024461-(3-Nitrophenyl)-3-phenyl-2-propen-1-oneHCID 517165Ammonium AcetateHCID 4076516N-(2-morpholin-4-ylethyl)-3-oxobutanamide

생성물 1

HCID 679263882-Methyl-3-(2-morpholinoethylcarbamoyl)-6-(3-nitrophenyl)-4-phenylpyridine dihydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Methyl-3-(2-morpholinoethylcarbamoyl)-6- 3-nitrophenyl)-4-phenylpyridine, which was obtained according to a similar manner to that of Example 1 from 1-(3-nitrophenyl)-3-phenyl-2-propen-1-one (3.8 g), N-(2-morpholinoethyl)acetoacetamide (5.8 g) and ammonium acetate (2.0 g), was treated with a solution of hydrogen chloride in methanol to give 2-methyl-3-(2-morpholinoethylcarbamoyl)-6-(3-nitrophenyl)-4-phenylpyridine dihydrochloride (1.92 g).

출처 및 근거

ORD 기록
ord-a18c357de71946848757b919118e0a47
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05037824

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