Isopropyl isocyanate → HCID 14799077, compound

HRID 2248031Notes

Reaction equation

HRID 2248031 reaction equation
[NH2:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][CH2:6][CH2:7][O:8][N+:9]([O-:11])=[O:10])=[O:4].[CH:14]([N:17]=[C:18]=[O:19])([CH3:16])[CH3:15]>C(OCC)(=O)C>[CH:14]([NH:17][C:18]([NH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][CH2:6][CH2:7][O:8][N+:9]([O-:11])=[O:10])=[O:4])=[O:19])([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 14799006HCID 14799006, compound

Product 1

HCID 14799077HCID 14799077, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
10 °C

Procedure

1.9 g. 2-Amino-2-methyl-N-(2-nitroxyethyl)-propionic acid amide is dissolved in 10 ml. ethyl acetate and mixed with 1.1 ml. isopropyl isocyanate while cooling with ice-water to 5° to 10° C. The reaction mixture is stirred for 2 hours at 10° C., filtered off with suction and washed with diethyl ether. There is obtained 1.4 g. of the title compound, i.e. 50% of theory; m.p. 120°-122° C.

Workup

  1. filtrationfiltered off with suction
  2. washwashed with diethyl ether
  3. customThere is obtained 1.4 g

Sources & evidence

ORD record
ord-35313ae408284478ad3d3ef9bed4c31e
Source dataset
uspto-grants-1991_08
Patent number
US05037849

Reaction notes

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