Potassium Iodide → HCID 15752534, compound

HRID 2248050Notes

Reaction equation

HRID 2248050 reaction equation
[CH3:1]N(C)C=O.[CH:6](=[O:18])[C:7]1[CH:17]=[C:14]([O:15][CH3:16])[C:12]([OH:13])=[C:9]([O:10][CH3:11])[CH:8]=1.[CH:19]1(Br)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.[I-].[K+]>O>[CH:19]1([CH2:1][O:13][C:12]2[C:14]([O:15][CH3:16])=[CH:17][C:7]([CH:6]=[O:18])=[CH:8][C:9]=2[O:10][CH3:11])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6228DimethylformamideHCID 7960Cyclohexyl bromideHCID 8655Syringaldehyde

Product 1

HCID 15752534HCID 15752534, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

49 g hydrogenated sodium was added to 1.8 lit. of N,N-dimethylformamide solution of 171.6 g of syringaldehyde, and these were stirred at 60° C. for 30 minutes. Under incubation on ice 200 g of cyclohexylbromide and 92 g of potassium iodide were further added, and the whole was stirred again at 80° C. for 1 hour. After cooling down, 1.5 lit. of water was poured to extract with ethylacetate. Then this was dried up with magnesium sulfate.

Workup

  1. stirringthe whole was stirred again at 80° C. for 1 hour
  2. temperatureAfter cooling down
  3. extractionto extract with ethylacetate
  4. dry with materialThen this was dried up with magnesium sulfate

Sources & evidence

ORD record
ord-b3470ca1582e48158be133b321592913
Source dataset
uspto-grants-1991_08
Patent number
US05037827

Reaction notes

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