Oxygen → HCID 14987203, compound

Temperature

-78 °C

To a flame dried flask containing 60 ml of anhydrous ethyl ether was added 5.63 g (46.5 mmoles) of cyclopropylbromide, and then the mixture was cooled to -78° C. under a nitrogen atmosphere. Then, 27.4 ml (46.5 mmoles) of 1.7M t-butyllithium was added slowly. The mixture was then warmed to -40° C. Into another flame dried flask was placed 2.95 g (15.5 mmoles) of 3-bromo-4-fluoroaniline and 50 ml of anhydrous tetrahydrofuran. This mixture was also cooled to -78° C. under nitrogen atmosphere. Then, 9.7 ml (15.5 mmoles) of 1.6M n-butyllithium was added to the second mixture which was stirred at -78° C. for 25 minutes followed by the addition of 1.39 g (15.5 mmoles) of cuprous cyanide. The mixture was then warmed to -40° C., stirred for 30 minutes at -40° C. and then cooled to -78° C. Then, the anilinocuprate was added via inverse addition by a cannula to the cyclopropyllithium/ether solution at -78° C. The reaction mixture was warmed to room temperature and maintained at room temperature overnight followed by heating to 35° C. in an oil bath for about 9 hours. The mixture was cooled to -78° C., oxygen was added for 5 minutes and then 100 ml of 1:1 concentrated ammonium hydroxide/saturated ammonium chloride was added. The mixture was warmed to room temperature, and the organic layer was washed three times with 1:1 ammonium hydroxide/ammonium chloride and twice with saturated brine. The resulting solution was dried over anhydrous sodium sulfate, suction filtered, concentrated in vacuo and column chromatographed on silica gel (20% ethyl acetate/hexanes, 1% triethylamine) to give the title compound as two components [1.03 g (28.9% yield) and 1.30 g (44.1%) yield].

1. customTo a flame dried flask
2. additioncontaining 60 ml of anhydrous ethyl ether
3. temperatureThe mixture was then warmed to -40° C
4. customInto another flame dried flask
5. temperatureThis mixture was also cooled to -78° C. under nitrogen atmosphere
6. temperatureThe mixture was then warmed to -40° C.
7. stirringstirred for 30 minutes at -40° C.
8. temperaturecooled to -78° C
9. temperatureThe reaction mixture was warmed to room temperature
10. temperaturemaintained at room temperature overnight
11. temperatureby heating to 35° C. in an oil bath for about 9 hours
12. temperatureThe mixture was cooled to -78° C.
13. temperatureThe mixture was warmed to room temperature
14. washthe organic layer was washed three times with 1:1 ammonium hydroxide/ammonium chloride
15. dry with materialThe resulting solution was dried over anhydrous sodium sulfate, suction
16. filtrationfiltered
17. concentrationconcentrated in vacuo and column
18. customchromatographed on silica gel (20% ethyl acetate/hexanes, 1% triethylamine)

ORD record

ord-1a35ed734b5148f8aa15d3aa2cfae6b8

Source dataset

uspto-grants-1991_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05039682