Benzaldehyde → HCID 19994129, compound

HRID 2249240Notes

Reaction equation

HRID 2249240 reaction equation
O.[CH3:2][CH:3]([OH:10])[CH2:4][NH:5][CH2:6][CH:7]([OH:9])[CH3:8].[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1C=CC=CC=1>[C:12]1([CH:11]2[N:5]([CH2:6][CH:7]([OH:9])[CH3:8])[CH2:4][CH:3]([CH3:2])[O:10]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 962WaterHCID 8086Diisopropanolamine

Product 1

HCID 19994129HCID 19994129, compoundYield 96.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A reaction vessel equipped with a thermometer, a dropping funnel, a stirrer and a condenser having a water separator was charged with 133 g of diisopropanolamine and 100 g of benzene, to which 107 g of benzaldehyde was added dropwise at room temperature for one hour. The content was heated to reflux and, after removing water produced during reacting, reacted for another 5 hours. Benzene was removed under a reduced pressure and then distilled at 125° to 127° C./1 mmHg to obtain 214 g of 2-phenyl-3-(2-hydroxypropyl)-5-methyloxazolidine.

Workup

  1. customA reaction vessel equipped with a thermometer, a dropping funnel, a stirrer and a condenser
  2. additionwas added dropwise at room temperature for one hour
  3. temperatureThe content was heated
  4. temperatureto reflux
  5. customafter removing water
  6. customproduced
  7. customreacted for another 5 hours
  8. customBenzene was removed under a reduced pressure
  9. distillationdistilled at 125° to 127° C./1 mmHg

Sources & evidence

ORD record
ord-a4118ed583974fac8d31300abfa67269
Source dataset
uspto-grants-1991_08
Patent number
US05043452

Reaction notes

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