反应详情

To a solution of 5-trichloroacetyl-1H-pyrrole-3-carbaldehyde (3.6 g, 14.97 mmol) in MeOH (60 mL) was added triethylamine (2 mL). The reaction mixture was stirred at room temperature for 3 hours. The solvent was removed and the residue was dried on the vacuum pump for 6 hours. This crude product was then dissolved in 60 mL of anhydrous THF. To the resulting solution was added NaH (720 mg, 18 mmol) at room temperature. The suspension was then stirred at room temperature for 1 hour before addition of MsCl (2.6 g, 22.70 mmol). The mixture was left at room temperature overnight and then poured into 2N HCl solution (100 mL). The aqueous solution was extracted with EtOAc (3×60 mL), the combined organic layers were dried over MgSO4, the solvent was removed by evaporation, and the residue was purified by flash column eluting with 30% EtOAc/hexanes to afford the title compound as a white solid (2.85 g, 82%). 1H NMR (500 MHz, DMSO-d6) δ9.88 (s, 1H), 8.40 (s, 1H), 7.40 (s, 1H), 3.96 (s, 3H), 3.85 (s, 3H) ppm. MS (ES+): m/e=232.1 (M+H); LC/Method A/2.61 min.

1. customThe solvent was removed
2. customthe residue was dried on the vacuum pump for 6 hours
3. dissolutionThis crude product was then dissolved in 60 mL of anhydrous THF
4. waitThe mixture was left at room temperature overnight
5. extractionThe aqueous solution was extracted with EtOAc (3×60 mL)
6. dry with materialthe combined organic layers were dried over MgSO4
7. customthe solvent was removed by evaporation
8. customthe residue was purified by flash column
9. washeluting with 30% EtOAc/hexanes