Methyl iodide → HCID 59642143, compound

HRID 2250858Notes

Reaction equation

HRID 2250858 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([S:8]([F:13])([F:12])([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[OH:14].[C:15]([O-])([O-])=O.[K+].[K+].CI>CN(C=O)C.CC(=O)OCC>[Cl:1][C:2]1[CH:7]=[C:6]([S:8]([F:13])([F:9])([F:10])([F:11])[F:12])[CH:5]=[CH:4][C:3]=1[O:14][CH3:15]

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 86599511Sulfur, (3-chloro-4-hydroxyphenyl)pentafluoro-, (OC-6-21)-

Product 1

HCID 59642143HCID 59642143, compoundYield 93.1%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

5.50 g of 2-chloro-4-pentafluorosulfanylphenol, 7.89 g of K2CO3 and 4.05 g of CH3I were stirred at RT in 30 ml of anhydrous DMF for 2 hours and left to stand at RT for 2 days. The mixture was then diluted with 300 ml of EA and washed 3 times with 100 ml each time of water. Drying was effected with Na2SO4 and the solvent was removed under reduced pressure to obtain 5.40 g of a pale yellow oil.

Workup

  1. waitleft
  2. washwashed 3 times with 100 ml each time of water
  3. customDrying
  4. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-163dcabc179c41cd98cec8c18a0f23c9
Source dataset
uspto-grants-2008_01
Patent number
US07317124B2

Reaction notes

Loading…