反应详情

温度

65 °C

4-(6,7-Dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-2-iodo-phenol (440 mg, 1.17 mmol), homopropargyl alcohol (147.3 mg, 2.1 mmol) and triethyl amine (295 mg, 2.92 mmol) were dissolved in DMF (15 ml). To this solution was added copper (I) iodide (66.3 mg, 0.34 mmol) and bis-triphenylphosphine palladium (II) chloride (81.9 mg, 0.117 mmol). The reaction was flushed with nitrogen and heated at 65° C. for 12 hours. Solvent was removed under reduced pressure and the residue purified on silica gel (10%-75% EtOAc in hexane) to give 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzofuran-2-yl]-ethanol.

1. customThe reaction was flushed with nitrogen
2. customSolvent was removed under reduced pressure
3. customthe residue purified on silica gel (10%-75% EtOAc in hexane)