Potassium Carbonate → HCID 59643624, compound

HRID 2251304Notes

Reaction equation

HRID 2251304 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:16][N:17]([CH3:36])[CH:18]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[CH:27][C:26]([C:29]3[N:33]=[C:32]([CH2:34][OH:35])[O:31][N:30]=3)=[CH:25][CH:24]=2)[CH2:19]1>CN(C=O)C>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][O:35][CH2:34][C:32]2[O:31][N:30]=[C:29]([C:26]3[CH:25]=[CH:24][C:23]([N:20]4[CH2:21][CH2:22][CH:18]([N:17]([CH3:36])[CH3:16])[CH2:19]4)=[CH:28][CH:27]=3)[N:33]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 680214-Fluorobenzyl bromideHCID 68574706HCID 68574706, compound

Product 1

HCID 59643624HCID 59643624, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

4-Fluorobenzyl bromide (18.9 mg) and potassium carbonate (27.6 mg) were added to a mixture of {3-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl][1,2,4]oxadiazol-5-yl}methanol (28.8 mg) and DMF (0.3 ml). The reaction mixture was stirred at 60° C. for 3 h, filtered and purified by preparative HPLC. The product with the molecular weight of 396.20 (C22H25FN4O2) was obtained in this way; MS (ESI): 397.27 (M+H+).

Workup

  1. filtrationfiltered
  2. custompurified by preparative HPLC
  3. customThe product with the molecular weight of 396.20 (C22H25FN4O2) was obtained in this way

Sources & evidence

ORD record
ord-740bffd8302248cc99fd09b89a5da476
Source dataset
uspto-grants-2008_01
Patent number
US07319108B2

Reaction notes

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