Lithium Hydroxide → HCID 58755377, compound

HRID 2251325Notes

Reaction equation

HRID 2251325 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[C:11]([C:18]3[C:23]([Cl:24])=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:25])=[N:12][O:13][C:14]=2[CH:15]([CH3:17])[CH3:16])[CH:5]=[CH:4][C:3]=1[NH:26][C:27]([C:29]1[CH:38]=[CH:37][C:32]([C:33]([O:35]C)=[O:34])=[CH:31][CH:30]=1)=[O:28].[OH-].[Li+]>O1CCCC1>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[C:11]([C:18]3[C:19]([Cl:25])=[CH:20][CH:21]=[CH:22][C:23]=3[Cl:24])=[N:12][O:13][C:14]=2[CH:15]([CH3:17])[CH3:16])[CH:5]=[CH:4][C:3]=1[NH:26][C:27]([C:29]1[CH:30]=[CH:31][C:32]([C:33]([OH:35])=[O:34])=[CH:37][CH:38]=1)=[O:28]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 58755345HCID 58755345, compound

Product 1

HCID 58755377HCID 58755377, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methyl 4-{[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)amino]carbonyl}benzoate (10 mg, 17 μmol) in tetrahydrofuran (150 μL) was stirred vigorously with aqueous lithium hydroxide (104 μL, 0.5M) at ambient temperature for 24 h. The reaction was partitioned with ethyl acetate and then dried over anhydrous sodium sulfate, filtered, and was condensed to a residue.

Workup

  1. customThe reaction was partitioned with ethyl acetate
  2. dry with materialdried over anhydrous sodium sulfate
  3. filtrationfiltered
  4. customcondensed to a residue

Sources & evidence

ORD record
ord-b198d387dec54cce8f9549398324e98c
Source dataset
uspto-grants-2008_01
Patent number
US07319109B2

Reaction notes

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