反应详情

To a solution of 3-bromo-5-trifluoromethyl-benzene-1,2-diol (510 mg, 1.98 mmol) in 10 mL acetone, K2CO3 (2.74 g, 19.84 mmol, 10 eq.) and benzyl bromide (1.02 g, 5.95 mmol, 3 eq.) were added and the solution was refluxed for 4 h. After cooling to r.t., H2O and EtOAc were added to the mixture and the phases were separated The organic fraction was washed with saturated NaCl solution, dried over MgSO4 and evaporated in vacuo. The crude product was purified using flash chromatography (silica gel, hexane/EtOAc 10:1) to yield the title compound as a colorless solid.

1. temperaturethe solution was refluxed for 4 h
2. customthe phases were separated The organic fraction
3. washwas washed with saturated NaCl solution
4. dry with materialdried over MgSO4
5. customevaporated in vacuo
6. customThe crude product was purified