Methylamine → HCID 23329097, compound

HRID 225168Notes

Reaction equation

HRID 225168 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:14])[CH2:9][CH2:10][C:11](O)=[O:12])=[CH:4][C:3]=1[S:15](=[O:18])(=[O:17])[NH2:16].O1CCCC1.ClC(OCC)=O.[CH3:30][NH2:31]>C(N(CC)CC)C>[OH:14][C:8]1([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([S:15](=[O:18])(=[O:17])[NH2:16])[CH:4]=2)[N:31]([CH3:30])[C:11](=[O:12])[CH2:10][CH2:9]1

Participants

6

Reactant 4

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 10928Ethyl chloroformateHCID 23329164HCID 23329164, compound

Product 1

HCID 23329097HCID 23329097, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

9.4 g of 4-(4-methyl-3-sulfamoylphenyl)-4-oxobutanoic acid are reacted analogously to the instructions indicated in Example 1 using 64 ml of absolute tetrahydrofurane, 6.7 ml of triethylamine, 4.7 ml of ethyl chloroformate and 90 ml of 40% strength aqueous methylamine solution to yield 5-hydroxyl-1-methyl-5-(4-methyl-3-sulfamoylphenyl)-2-oxopyrrolidine.

Sources & evidence

ORD record
ord-29bd49aa0ff44f1e9e1370a7e1bb543b
Source dataset
uspto-grants-1980_11
Patent number
US04235918

Reaction notes

Loading…