1,1'-Carbonyldiimidazole → N-(5-hydroxy-5,5-diphenyl-pentyl)-3-pyridin-3-yl-acrylamide

HRID 2251927Notes

Reaction equation

HRID 2251927 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[OH:24][C:25]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:26][CH2:27][CH2:28][CH2:29][NH2:30]>C1COCC1>[OH:24][C:25]([C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[CH2:26][CH2:27][CH2:28][CH2:29][NH:30][C:9](=[O:11])[CH:8]=[CH:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 179407425-Hydroxy-5,5-diphenyl-pentylamine

Product 1

HCID 54276084N-(5-hydroxy-5,5-diphenyl-pentyl)-3-pyridin-3-yl-acrylamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Batch size: 1.7 g (11.3 mmol) 3-(3-pyridyl)-acrylic acid, 1.7 g (10 mmol) CDI and 2.4 g (9.4 mmol) 5-hydroxy-5,5-diphenyl-pentylamine in 40 ml abs. THF.

Sources & evidence

ORD record
ord-dfafbaa946f94283963a6a1ed739b8cf
Source dataset
uspto-grants-2008_01
Patent number
US07320993B1

Reaction notes

Loading…