Tetrahydrofuran → HCID 69201252, compound

HRID 2252249Notes

Reaction equation

HRID 2252249 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[CH2:13][CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH2:21]1[CH2:25][O:24][CH2:23][CH2:22]1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[CH:13]([C:14]([C:15]1[CH:11]=[CH:12][C:22]3[C:17](=[CH:9][CH:10]=[C:25]([O:24][CH3:23])[CH:21]=3)[CH:16]=1)=[O:18])[CH2:12]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 107524065-(benzyloxy)-2,3-dihydro-1H-inden-1-one

Product 1

HCID 69201252HCID 69201252, compound

Procedure

5-Benzyloxyindanone (1.5 g, 6.29 mmol) was treated with NaH (60%, 377 mg) in THF (50 mL), and then Example 168A (1.59 g) was added. The reaction was stirred for 6 hours at room temperature. The precipitates were collected by filtration and dissolved in water, acidified with concentrated HCl, and the resulting precipitates were collected, washed with water and dried to give the title compound.

Workup

  1. filtrationThe precipitates were collected by filtration
  2. dissolutiondissolved in water
  3. customthe resulting precipitates
  4. customwere collected
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-a5e9da07e40643d0a40732639f5ba7d8
Source dataset
uspto-grants-2008_01
Patent number
US07320986B2

Reaction notes

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