3-Hydroxypyridine → 4-(Pyridin-3-yloxy)-phthalonitrile

HRID 2253180Notes

Reaction equation

HRID 2253180 reaction equation
[N+]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9])([O-])=O.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:4]2[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=2)[C:8]#[N:9])[CH:15]=1

Participants

5

Reactant 3

HCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 974431,2-Benzenedicarbonitrile, 4-nitro-

Product 1

HCID 8822734-(Pyridin-3-yloxy)-phthalonitrileYield 187.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4-nitro-phthalonitrile (3.46 g, 20 mmol), pyridin-3-ol (1.90 g, 20 mmol), K2CO3 (8.29 g, 60 mmol), and DMF (50 ml) was stirred at ambient temperature overnight. The reaction mixture was then combined with another batch of the same reaction performed on the same scale. Subsequently, the solid components were removed by filtration and the filtrate was concentrated in vacuo. To the residue was added water and the mixture was extracted with EtOAc. The organic phase was then washed with brine, dried, and evaporated in vacuo. The residue was recrystallized from EtOAc/MeOH to give 8.3 g of the title compound; 1H NMR (CDCl3): δ=8.56 to 8.59 (m, 1H), 8.45 to 8.47 (m, 1H), 7.76 (d, 1H), 7.42 to 7.44 (m, 2H), 7.22 to 7.32 (m, 2H).

Workup

  1. customThe reaction mixture was then combined with another batch of the same reaction
  2. customSubsequently, the solid components were removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo
  4. additionTo the residue was added water
  5. extractionthe mixture was extracted with EtOAc
  6. washThe organic phase was then washed with brine
  7. customdried
  8. customevaporated in vacuo
  9. customThe residue was recrystallized from EtOAc/MeOH

Sources & evidence

ORD record
ord-5cf5832000b342da92571d81c06fb5d0
Source dataset
uspto-grants-2008_01
Patent number
US07323475B2

Reaction notes

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