反应详情

温度

60 °C

Pd2(dba)3 (5.6 mg, 5.12 μmol) and dppf (2.83 mg, 5.09 μmol) were added to a degassed (N2 for 30 min) mixture of tert-butyl {3-[4-bromo-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-7,9-dioxo-1,6,7,9-tetrahydro-8H-imidazo[4,5-h]isoquinolin-8-yl]propyl}[2-(3,4-dimethoxyphenyl)ethyl]carbamate (780 mg, 1.02 mmol), 4-methoxybenzylamine (533 μL, 4.08 mmol) and NaOt-Bu (196 mg, 2.04 mmol) in THF (10.2 mL). The reaction mixture was stirred at 60° C. for 3 h, then was concentrated under reduced pressure. The residue was purified by flash chromatography (40-63μ silica gel; CH2Cl2:acetone 95:5) to give the title compound (542 mg, 65% yield).

1. customa degassed
2. concentrationwas concentrated under reduced pressure
3. customThe residue was purified by flash chromatography (40-63μ silica gel; CH2Cl2:acetone 95:5)