Toluene → HCID 19738050, compound

HRID 2255371Notes

Reaction equation

HRID 2255371 reaction equation
Cl[CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH3:12])[CH2:6]1.[H-].[Na+].[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([CH2:20][C:21]#[N:22])=[CH:18][CH:17]=1.C1(C)C=CC=CC=1>CN(C=O)C>[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([CH:20]([CH2:2][CH2:3][CH2:4][N:5]2[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH3:12])[CH2:6]2)[C:21]#[N:22])=[CH:18][CH:17]=1

Participants

6

Reactant 4

HCID 1140TolueneHCID 24758Sodium hydrideHCID 2415824-Chlorobenzyl cyanideHCID 197380174-(3-Chloropropyl)-2,6-dimethylmorpholine

Product 1

HCID 19738050HCID 19738050, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This intermediate (2.0 g.) was prepared using the procedure described in Example 2a except using 2.3 g. (11 moles) of 4-(3-chloropropyl)-2,6-dimethylmorpholine, 0.48 g. of sodium hydride, and 1.69 g. (11 mmoles) of 4-chlorobenzyl cyanide in 15 ml. of a 2 to 1 mixture of toluene and DMF and was isolated as a pale yellow oil.

Workup

  1. customThis intermediate (2.0 g.) was prepared
  2. customwas isolated as a pale yellow oil

Sources & evidence

ORD record
ord-78d7f8d414b24a0c95ca254035ff6810
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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