Sodium hydride → HCID 19738056, compound

HRID 2255372Notes

Reaction equation

HRID 2255372 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH:18]([CH3:20])[O:17][CH:16]([CH3:21])[CH2:15]2)[C:9]#[N:10])=[CH:4][CH:3]=1.Cl[CH2:23][N:24]1[CH:28]=[N:27][CH:26]=[N:25]1.[H-].[Na+]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]#[N:10])([CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH:16]([CH3:21])[O:17][CH:18]([CH3:20])[CH2:19]2)[CH2:23][N:24]2[CH:28]=[N:27][CH:26]=[N:25]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 37438821-Chloromethyl-1H-1,2,4-triazoleHCID 19738050HCID 19738050, compound

Product 1

HCID 19738056HCID 19738056, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound (1.2 g.) was prepared using the procedure described in Example 2b except using 1.0 g. (3.3 mmoles) of 2-(4-chlorophenyl)-5-(2,6-dimethyl-4-morpholinyl)valeronitrile, 0.38 g. (3.3 mmoles) of 1-(chloromethyl)-1,2,4-triazole, and 0.16 g. (3.6 mmoles) of sodium hydride in 35 ml. of DMF and was isolated as a yellow oil.

Workup

  1. customThis compound (1.2 g.) was prepared

Sources & evidence

ORD record
ord-5378a2322146465996f8d4a91253da0c
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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