Sodium hydride → HCID 53704383, compound

HRID 2255377Notes

Reaction equation

HRID 2255377 reaction equation
Cl.Cl[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH2:12][CH:11]([CH3:13])[O:10][CH:9]([CH3:14])[CH2:8]1.[H-].[Na+].[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([CH2:22][C:23]#[N:24])=[CH:20][CH:19]=1>CN(C=O)C>[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([CH:22]([CH2:3][CH2:4][CH2:5][CH2:6][N:7]2[CH2:12][CH:11]([CH3:13])[O:10][CH:9]([CH3:14])[CH2:8]2)[C:23]#[N:24])=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 2415824-Chlorobenzyl cyanideHCID 197380244-(4-Chlorobutyl)-2,6-dimethylmorpholine hydrochloride

Product 1

HCID 53704383HCID 53704383, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This intermediate (400 mg.) was prepared using the procedure described in Example 2a except using 1.0 g. (4.13 mmoles) of 4-(4-chlorobutyl)-2,6-dimethylmorpholine hydrochloride, 1.81 g. (0.021 mole) of sodium hydride, and 3.18 g. (0.021 mole) of 4-chlorobenzyl cyanide in 40 ml. of DMF.

Workup

  1. customThis intermediate (400 mg.) was prepared

Sources & evidence

ORD record
ord-810bb6e4eaed421c8dfdf8eb024a1639
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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