Sodium hydride → HCID 19738035, compound

HRID 2255382Notes

Reaction equation

HRID 2255382 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH:26]([CH3:28])[O:25][CH:24]([CH3:29])[CH2:23]2)[C:9]#[N:10])=[CH:4][CH:3]=1.[H-].[Na+].Cl[CH2:33][N:34]1[CH:38]=[N:37][CH:36]=[N:35]1>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]#[N:10])([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:23][CH:24]([CH3:29])[O:25][CH:26]([CH3:28])[CH2:27]2)[CH2:33][N:34]2[CH:38]=[N:37][CH:36]=[N:35]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 37438821-Chloromethyl-1H-1,2,4-triazoleHCID 19738034HCID 19738034, compound

Product 1

HCID 19738035HCID 19738035, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound (350 mg.) was prepared using the procedure described in Example 2b except using 500 mg. (1.25 mmoles) of 2-(4-chlorophenyl)-13-(2,6-dimethyl-4-morpholinyl)tridecanonitrile, 60 mg (1.35 mmoles) of sodium hydride, 150 mg. (1.25 mmoles) of 1-(chloromethyl)-1,2,4-triazole, and 15 ml. of DMF and was isolated as an amber oil.

Workup

  1. customThis compound (350 mg.) was prepared

Sources & evidence

ORD record
ord-c6ca4e0018b141a0aa0b22dcc4e2f623
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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