Hydrochloric Acid → HCID 19737967, compound

HRID 2255503Notes

Reaction equation

HRID 2255503 reaction equation
[OH:1][CH:2]1[C:7]2[CH:8]=[CH:9][S:10][C:6]=2[S:5](=[O:12])(=[O:11])[N:4]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:3]1.C([Li])CCC.[S:26](=[O:28])=[O:27].[NH2:29]OS(O)(=O)=O.[ClH:35]>>[ClH:35].[OH:1][CH:2]1[C:7]2[CH:8]=[C:9]([S:26]([NH2:29])(=[O:28])=[O:27])[S:10][C:6]=2[S:5](=[O:12])(=[O:11])[N:4]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:3]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 76284hydroxylamine-O-sulfonic acidHCID 19874047HCID 19874047, compoundHCID 178418339Butyllithium

Product 1

HCID 19737967HCID 19737967, compound

Procedure

The product from Step A (1.84 g, 5.79 mmol) was treated sequentially with n-butyllithium (2.2 equivalents), sulfur dioxide, hydroxylamine-O-sulfonic acid and methanolic HCl in much the same was as described in Example 4 to furnish the desired product as a white solid: mp 118°-125° C.

Sources & evidence

ORD record
ord-bf7fd0f61d604d198422416f82eea0be
Source dataset
uspto-grants-1993_08
Patent number
US05240923

Reaction notes

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