2-Amino-2-methyl-1,3-propanediol → HCID 53739728, compound

HRID 2255825Notes

Reaction equation

HRID 2255825 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].Br[CH2:7][C:8]1[C:25]2[C:24]3[C:15](=[C:16]4[C:21](=[CH:22][CH:23]=3)[CH:20]=[CH:19][CH:18]=[CH:17]4)[CH:14]=[CH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1.[NH2:26][C:27]([CH3:32])([CH2:30]O)[CH2:28][OH:29]>CC(O)C.CCOCC>[CH3:1][S:2]([O:5][CH2:30][C:27]([NH:26][CH2:7][C:8]1[C:25]2[C:24]3[C:15](=[C:16]4[C:21](=[CH:22][CH:23]=3)[CH:20]=[CH:19][CH:18]=[CH:17]4)[CH:14]=[CH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)([CH3:32])[CH2:28][OH:29])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 6395Methanesulfonic AcidHCID 15050900HCID 15050900, compound

Product 1

HCID 53739728HCID 53739728, compoundYield 27.5%

Reagents, catalysts & solvents 1

HCID 22147583Diethyl ether 2-propanolSolvent

Procedure

Using the procedure outlined in Example 3D except that the crude free base was treated with methanesulfonic acid, 4-bromomethylchrysene (10A) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave a 27.5% yield of 2-[(4-chrysenylmethyl)amino]-2-methyl-1,3-propanediol methanesulfonate 0.4 H2O 0.1 i-PrOH, mp 192°-193.5° (C,H,N,S), (i-PrOH/Et2O).

Sources & evidence

ORD record
ord-3b4bd2ea9a5541bca0b9896eade2ef67
Source dataset
uspto-grants-1993_08
Patent number
US05241107

Reaction notes

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