Hydrochloric Acid → HCID 131718333, compound

HRID 2256842Notes

Reaction equation

HRID 2256842 reaction equation
[NH:1]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:20][S:21]([NH2:24])(=[O:23])=[O:22].Cl>CN(C=O)C>[NH:1]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:20][S:21]([NH2:24])(=[O:23])=[O:22]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 72879MethanesulfonamideHCID 637610Boc-D-phenylalanine

Product 1

HCID 131718333HCID 131718333, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Boc-D-Phe-OH (0.20 g), methanesulfonamide (79 mg) DMAP (0.11 g), WSCD.HCl (0.17 g) and DMF (4 ml) were reacted in a similar manner to that of Preparation 1-1) to give Boc-D-Phe-methanesulfonamide (0.21 g).

Workup

  1. customof Preparation 1-1)

Sources & evidence

ORD record
ord-f99f55940e6b41feaa8eeac0ecc3510e
Source dataset
uspto-grants-1997_08
Patent number
US05656604

Reaction notes

Loading…