Trifluoroacetic acid → HCID 19028005, compound

HRID 2257129Notes

Reaction equation

HRID 2257129 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[C:4]=1[C:12]1[N:13]=[C:14]([NH:17][C:18]([C:20]2[N:21]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:19])[S:15][CH:16]=1.[C:37]([OH:43])([C:39]([F:42])([F:41])[F:40])=[O:38]>C1(OC)C=CC=CC=1>[F:40][C:39]([F:42])([F:41])[C:37]([OH:43])=[O:38].[CH3:11][O:10][C:5]1[CH:6]=[C:7]([CH3:9])[CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:12]1[N:13]=[C:14]([NH:17][C:18]([C:20]2[N:21]([CH2:29][C:30]([OH:32])=[O:31])[C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:19])[S:15][CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19028030HCID 19028030, compound

Product 1

HCID 19028005HCID 19028005, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

1.07 g of N-[4-(2,6-dimethoxy-4-methylphenyl)-2-thiazolyl]-1-(tert-butoxycarbonylmethyl)indole-2-carboxamide (prepared according to EP-A-0,432,040) are dissolved in a mixture of 2 ml of anisole and 20 ml of TFA. The reaction mixture is left for 3/4 hour at r.t. and then concentrated under vacuum. The residue is taken up in ether, and the precipitate is then filtered off and dried in an oven to obtain 1.13 g of the expected compound; m.p.=223°-224° C.

Workup

  1. waitThe reaction mixture is left for 3/4 hour at r.t.
  2. concentrationconcentrated under vacuum
  3. filtrationthe precipitate is then filtered off
  4. customdried in an oven

Sources & evidence

ORD record
ord-721c021cf296420493a240630607f113
Source dataset
uspto-grants-1997_08
Patent number
US05656648

Reaction notes

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