反应详情

A solution of 2-(1-cyclohexenyl) ethyl isothiocyanate (3.3 g, 20 mmol) and 2-aminothiazole (2.0 g, 20 mmol) in N,N-dimethylformamide (20 mL) was heated at 100° C. for 24 h. The reaction was cooled to room temperature, poured into ethyl acetate, washed with water, 1N aqueous HCl, water, saturated sodium bicarbonate, and brine. The organic layer was concentrated and the residue recrystallized from ethyl acetate to provide 2.66 g (50%) of the title product:

1. washwashed with water, 1N aqueous HCl, water, saturated sodium bicarbonate, and brine
2. concentrationThe organic layer was concentrated
3. customthe residue recrystallized from ethyl acetate