Water → HCID 22923678, compound

HRID 2257900Notes

Reaction equation

HRID 2257900 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2.[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[I-].[Na+].O>CN(C)C=O>[CH2:18]([NH:25][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 962WaterHCID 5238Sodium IodideHCID 7504BenzylamineHCID 22923693HCID 22923693, compound

Product 1

HCID 22923678HCID 22923678, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A suspension of 30 g of 6-(4-chlorobutoxy)-carbostyril, 103 ml of benzylamine and 33 g of sodium iodide in 300 ml of dimethylformamide was stirred at 80° C. for 8 hours. The reaction mixture was allowed to cool and then poured into water. The resulting precipitate was collected by filtration. The precipitate was washed with water and diethyl ether in this order to obtain 29.1 g of 6-(4-benzylaminobutoxy)carbostyril.

Workup

  1. temperatureto cool
  2. filtrationThe resulting precipitate was collected by filtration
  3. washThe precipitate was washed with water and diethyl ether in this order

Sources & evidence

ORD record
ord-b4424247e90746e89c51de3cdacbf121
Source dataset
uspto-grants-1997_08
Patent number
US05658926

Reaction notes

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