1-Bromopropane → HCID 178460919, compound

HRID 2258163Notes

Reaction equation

HRID 2258163 reaction equation
[CH3:1][CH2:2][CH2:3]Br.[Mg].Cl[SiH:7]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[CH:15][CH:14]=2)[CH2:9][CH2:8]1>O1CCCC1>[CH2:3]([Si@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)[CH2:2][CH3:1]

Participants

5

Reactant 3

HCID 78401-BromopropaneHCID 5462224MagnesiumHCID 123646023HCID 123646023, compound

Product 1

HCID 178460919HCID 178460919, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Procedure

2.5 g (20 mmol) of n-propyl bromide was dripped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of tetrahydrofuran (hereafter abbreviated as "THF") to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 6.1 g (20 mmol) of 4'-(4-chloro-4-silacyclohexyl)-4-fluorobiphenyl to obtain 4'-(trans-4-n-propyl-4-silacyclohexyl)-4-fluorobiphenyl.

Workup

  1. customto obtain a Grignard's reagent

Sources & evidence

ORD record
ord-326f9328c527457fae88d78532430937
Source dataset
uspto-grants-1997_08
Patent number
US05659059

Reaction notes

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