反应详情

To a being cooled suspension of 7-chloro-2-[2,4-bis-(methoxycarbonyl)phenoxymethyl]quinoline (0.3 g) in N,N-dimethylformamide (6 ml), sodium hydride ((60% in mineral oil) 31 mg). After being stirred at same temperature for 30 minutes and successively at ambient temperature for 3 hours, the resulting mixture was poured into a mixture of ethyl acetate and buffer (pH 4.1). The appeared precipitates were collected by filtration and washed with n-hexane to give 7-chloro-2-(5-methoxycarbonyl-3-hydroxybenzofuran-2-yl)quinoline (0.15

1. temperatureTo a being cooled
2. customThe appeared precipitates
3. filtrationwere collected by filtration
4. washwashed with n-hexane