Ethanol → HCID 22922498, compound

HRID 2258539Notes

Reaction equation

HRID 2258539 reaction equation
[O-:1][CH2:2][CH3:3].[Na+].[Na].Cl.[NH2:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9]1.Cl[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[C:20]([N+]([O-])=O)[CH:19]=1.C[CH2:31][OH:32]>>[CH2:2]([O:1][C:18]1[CH:23]=[CH:22][C:21]2[NH:24][C:31](=[O:32])[N:7]([CH:8]3[CH2:16][C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[CH2:9]3)[C:20]=2[CH:19]=1)[CH3:3]

Participants

6

Reactant 5

HCID 702EthanolHCID 330974-Chloro-1,2-dinitrobenzeneHCID 1227642-Aminoindan hydrochlorideHCID 2723922Sodium ethoxideHCID 5360545Sodium

Product 1

HCID 22922498HCID 22922498, compound

Procedure

To sodium ethoxide solution, prepared from 0.61 g of sodium in 200 ml of EtOH, are added 26 g of 2-aminoindane hydrochloride and then 20 g of 4-chloro-1,2-dinitrobenzene and the mixture is left stirring for 48 hours at RT. The solvent is evaporated off under vacuum, the residue is extracted with EtOAc, washed with water and dried over Na2SO4, and the solvent is evaporated off under vacuum. 10.3 g of the expected product are obtained after crystallization from EtOH, mp=108° C.

Workup

  1. customThe solvent is evaporated off under vacuum
  2. extractionthe residue is extracted with EtOAc
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

Sources & evidence

ORD record
ord-470450efdb94493295e07a1b5c7f0c15
Source dataset
uspto-grants-1997_08
Patent number
US05661169

Reaction notes

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