6-Bromoquinoline → 6-Bromoquinoline

HRID 2259130Notes

Reaction equation

HRID 2259130 reaction equation
Brc1ccc2ncccc2c1.Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O>CC(=O)[O-].CC(=O)[O-].CN(C)C=O.O=C([O-])O.[Na+].[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1.Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1.c1ccc2ncccc2c1.c1cnc2ccc(-c3ccc4ncccc4c3)cc2c1

Participants

11

Reactant 2

HCID 792436-BromoquinolineHCID 129009568[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid

Product 6

HCID 7047QuinolineYield 0%HCID 792436-BromoquinolineYield 69.295%HCID 6207116,6'-BiquinolineYield 0%HCID 10751213HCID 10751213, compoundYield 0%HCID 129009568[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acidYield 30.705%HCID 178422846HCID 178422846, compoundYield 0%

Reagents, catalysts & solvents 3

HCID 516892Sodium BicarbonateReagentHCID 167845palladium(II) acetateCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-08dce0c8e91f46e781170b34ba769af1
Source dataset
HTE Suzuki coupling dataset

Reaction notes

Loading…