Potassium Iodide → HCID 15752534, compound

HRID 2260195Notes

Reaction equation

HRID 2260195 reaction equation
[CH3:1]N(C)C=O.[CH3:6][O:7][C:8]1[C:13]([OH:14])=[C:12]([O:15][CH3:16])[CH:11]=[C:10]([CH:17]=[O:18])[CH:9]=1.[CH:19]1(Br)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.[I-].[K+]>O>[CH:19]1([CH2:1][O:14][C:13]2[C:12]([O:15][CH3:16])=[CH:11][C:10]([CH:17]=[O:18])=[CH:9][C:8]=2[O:7][CH3:6])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6228DimethylformamideHCID 7960Cyclohexyl bromideHCID 8655Syringaldehyde

Product 1

HCID 15752534HCID 15752534, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

49 g hydrogenated sodium was added to 1.8 lit. of N,N-dimethylformamide solution of 171.6 g of springaldehyde, and these were stirred at 60° C. for 30 minutes. Under incubation on ice 200 g of cyclohexylbromide and 92 g of potassium iodide were further added, and the whole was stirred again at 80° C. for 1 hour. After cooling down, 1.5 lit. of water was poured to extract with ethylacetate. Then this was dried up with magnesium sulfate.

Workup

  1. stirringthe whole was stirred again at 80° C. for 1 hour
  2. temperatureAfter cooling down
  3. extractionto extract with ethylacetate
  4. dry with materialThen this was dried up with magnesium sulfate

Sources & evidence

ORD record
ord-fa1d4a5147d340668e9aa924f87bb744
Source dataset
uspto-grants-1995_12
Patent number
US05476863

Reaction notes

Loading…