Ammonia → Amphetamine

HRID 2260808Notes

Reaction equation

N.[CH2:2]([NH2:4])[CH3:3].N[CH2:6][CH2:7]S(O)(=O)=O.CN[CH2:14][CH2:15]S(O)(=O)=O.CN.[CH2:22](N)[CH2:23]C.[CH2:26](CN)O.NCCC(O)=O.ClCCN.NC1C=CC=CC=1.CNC1C=CC=CC=1.C(NC1C=CC=CC=1)C>>[C:7]1([CH2:3][CH:2]([NH2:4])[CH3:26])[CH:6]=[CH:15][CH:14]=[CH:23][CH:22]=1

Participants

Reactant 12

HCID 7515N-Methylaniline

HCID 7670N-Ethylaniline

HCID 7852Propylamine

HCID 7882N-Methyltaurine

HCID 133692-Chloroethylamine

Product 1

HCID 3007Amphetamine

Procedure

Among them, particularly preferable are ammonia, ethylamine, taurine, N-methyltaurine, methylamine, n-propylamine, monoethanolamine, β-alanine, 2-chloroethylamine, 2-sulfatoethylamine, aniline, aniline-2-, -3- or -4-sulfonic acid, 2-, 3- or 4-carboxyaniline, N-methylaniline, N-ethylaniline, N-ethyl-2-, -3- or -4-chloroaniline, aniline-2,4- or -2,5-disulfonic acid, 2-, 3- or 4-chloroaniline, 2-, 3- or 4-methylaniline, 3- or 4-methylaminobenzenesulfonic acid, and the like.

Sources & evidence

ORD record: ord-f7a54db666a745e5bdf4404d929ad191
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05478936

Reaction notes

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