Nitrogen → 3-(1,5-dimethyl-1H-indol-2-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

HRID 226089Notes

Reaction equation

[CH2:1]([CH:3]([C:6]1[C:7]2[N:8]([C:13](I)=[C:14]([CH3:16])[N:15]=2)[N:9]=[C:10]([CH3:12])[CH:11]=1)[CH2:4][CH3:5])[CH3:2].C([C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[C:29]=1[N:28]([CH3:30])[C:27](C)=[CH:26]2)(C)C.[C:32]([O-])([O-])=O.[Cs+].[Cs+].N#N>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].CCOC(C)=O.CN(C=O)C>[CH3:30][N:28]1[C:29]2[C:25](=[CH:24][C:23]([CH3:32])=[CH:22][CH:21]=2)[CH:26]=[C:27]1[C:13]1[N:8]2[N:9]=[C:10]([CH3:12])[CH:11]=[C:6]([CH:3]([CH2:4][CH3:5])[CH2:1][CH3:2])[C:7]2=[N:15][C:14]=1[CH3:16]

Participants

Conditions

Temperature: 130 °C

Procedure

A solution of 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.30 g, 0.87 mmol), 7-isopropyl-1,2-dimethyl-1H-indole (0.33 g, 1.76 mmol), Cs2CO3 (0.57 g, 1.75 mmol), and DMF (5 mL), is degassed with N2 for 20 minutes. Pd2(dba)3 (0.040 g, 0.044 mmol is added and the solution is heated at 130° C. overnight. The solution is diluted EtOAc (30 mL) washed with water (2×30 mL), brine (30 mL) dried over MgSO4, filtered and concentrated. The residue is purified by ISCO (20%-30% EtOAc gradient) to furnish the title compound (0.017 g, 0.042 mmol, 4.8%). 1H NMR (CDCl3), δ 1.14-1.46 (m, 6H), 1.76-1.95 (m, 4H), 2.30 (s, 3H), 2.42 (s, 3H), 2.45 (s, 3H), 3.38-3.48 (m, 1H), 3.86-3.97 (m, 1H), 4.04 (s, 3H), 6.64 (s, 1H), 6.99-7. LC/MS (m/z): calcd. for C26H34N4 (M+H)+: 403.3. found: 403.4.

Workup

washwashed with water (2×30 mL), brine (30 mL)
dry with materialdried over MgSO4
filtrationfiltered
concentrationconcentrated
customThe residue is purified by ISCO (20%-30% EtOAc gradient)

Sources & evidence

ORD record: ord-4b88e88b30e848ef86f7e9f09dd5565f
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557103B2

Reaction notes

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