Hydrogen Peroxide → 5-Chloro-4-iodo-3-(pentan-3-ylamino)picolinamide

HRID 2262688Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2262688
[Cl:1][C:2]1[C:3]([I:16])=[C:4]([NH:10][CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.C(=O)([O-])[O-:18].[K+].[K+].OO>CS(C)=O.CCOC(C)=O>[Cl:1][C:2]1[C:3]([I:16])=[C:4]([NH:10][CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])[C:5]([C:8]([NH2:9])=[O:18])=[N:6][CH:7]=1

Komponenten

6

Edukt 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 595945725-Chloro-4-iodo-3-(pentan-3-ylamino)picolinonitrile

Produkt 1

HCID 595945475-Chloro-4-iodo-3-(pentan-3-ylamino)picolinamideAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 5-chloro-4-iodo-3-(pentan-3-ylamino)picolinonitrile (55 mg, 0.16 mmol) in DMSO (1 mL) was added solid potassium carbonate (210 mg, 0.64 mmol). The mixture was cooled in an ice water bath (0° C.) and aqueous hydrogen peroxide (30%, 0.5 mL) was added. The reaction was allowed to warm to room temperature and monitored by LCMS. After the reaction was complete, the reaction mixture was diluted with EtOAc, and the organic layer was washed repeatedly with water. The organic layer was then dried over sodium sulfate, filtered and concentrated in vacuo. The residue was filtered through a silica gel plug to provide the title compound as a white solid (50 mg, 83%). m/z=368.1 [M+H]+ and 1H NMR.

Aufarbeitung

  1. additionwas added
  2. washthe organic layer was washed repeatedly with water
  3. dry with materialThe organic layer was then dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. filtrationThe residue was filtered through a silica gel plug

Quellen und Nachweise

ORD-Eintrag
ord-03d0df28b8b74708bbfe38ab16646413
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851484B2

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