Hydrochloric Acid → HCID 68779467, compound

HRID 2262895Notes

Reaction equation

HRID 2262895 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[S:23][N:22]=[C:21]([N:24]4[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]4)[N:20]=3)[CH2:15][CH2:14]2)=[O:12])=[N:2]1.[ClH:37]>O1CCCC1.CO.C(OCC)(=O)C>[ClH:37].[ClH:37].[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:11]([N:13]2[CH2:14][CH2:15][N:16]([C:19]3[S:23][N:22]=[C:21]([N:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[N:20]=3)[CH2:17][CH2:18]2)=[O:12])=[N:2]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 68779465HCID 68779465, compound

Product 1

HCID 68779467HCID 68779467, compoundYield 65.6%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl 4-(5-{4-[(1,2-benzisoxazol-3-ylamino)carbonyl]piperazin-1-yl}-1,2,4-thiadiazol-3-yl)piperazine-1-carboxylate (87.0 mg, 0.169 mmol) in tetrahydrofuran (5 ml) and methanol (3 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (8 ml), and the mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 50.0 mg (65.6%) of the desired product.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and diethyl ether

Sources & evidence

ORD record
ord-c8410df6b68247cfaa7dc7771b8db415
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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