Triethylamine → HCID 59594488, compound

HRID 2263227Notes

Reaction equation

HRID 2263227 reaction equation
[C:1]1([C:7]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([N:31]=[C:32]=[S:33])[CH:26]=1>O1CCCC1>[C:1]1([C:7]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][N:15]([C:32](=[S:33])[NH:31][C:27]4[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=4)[CH2:14][CH2:13]3)[S:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27372423-Pyridyl isothiocyanateHCID 27777601-(3-Phenyl-(1,2,4)thiadiazol-5-yl)-piperazine

Product 1

HCID 59594488HCID 59594488, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (246 mg, 1.00 mmol) and triethylamine (0.139 ml, 1.00 mmol) in tetrahydrofuran (6 ml) was added 3-pyridylisothiocyanate (0.167 ml, 1.50 mmol), the mixture was stirred at room temperature for 3 hours and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of tetrahydrofuran and ethyl acetate to obtain the desired product (233 mg, 61.0%) as a solid.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of tetrahydrofuran and ethyl acetate

Sources & evidence

ORD record
ord-0ceeb4bd15ce47a4a360a5451d080860
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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